PEG-MGF

PEG-MGF (PEGylated Mechano Growth Factor) is a modified form of MGF with polyethylene glycol conjugation to extend its biological half-life. This modification enhances systemic stability for research applications.

Mechanism of Action

PEG-MGF retains the satellite cell-activating properties of native MGF while the PEG moiety extends half-life from minutes to hours. The E domain of MGF peptide is anti-apoptotic and a stem cell homing factor (Doroudian et al., 2014). MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells, enhancing their fusion potential for muscle repair (Kandalla et al., 2011).

Research Applications

• Extended MGF activity studies (Doroudian et al., 2014)
• Systemic muscle repair research
• PEGylation pharmacokinetics
• Satellite cell activation (Kandalla et al., 2011)
• Cardiac regeneration research

Product Specifications

• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C

References

1. Doroudian G, et al. “Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes.” Bioeng Transl Med. 2014. PMID: 24908137
2. Kandalla PK, et al. “Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.” Mech Ageing Dev. 2011. PMID: 21354439