MGF

MGF (Mechano Growth Factor) is a splice variant of IGF-1 produced locally in muscle tissue in response to mechanical stress. This autocrine growth factor initiates satellite cell activation and muscle hypertrophy.

Mechanism of Action

MGF is expressed in response to mechanical signals and muscle damage, activating quiescent satellite cells to begin the repair process. The MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells, enhancing their fusion potential at different ages (Kandalla et al., 2011). MGF is a putative product of IGF-I gene expression involved in tissue repair and regeneration (Goldspink, 2010).

Research Applications

• Muscle repair and regeneration (Kandalla et al., 2011)
• Satellite cell activation (Goldspink, 2010)
• IGF-1 splice variant research
• Mechanical signaling pathways
• Sarcopenia and muscle aging

Product Specifications

• Purity: ≥99% (HPLC verified)
• Molecular Weight: ~2800 Da
• Form: Lyophilized powder
• Storage: -20°C

References

1. Kandalla PK, et al. “Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.” Mech Ageing Dev. 2011. PMID: 21354439
2. Goldspink G. “Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.” Endocrinology. 2010. PMID: 20130113