5-Amino-1MQ

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor studied for its effects on cellular metabolism and energy regulation. This compound blocks the enzyme that converts NAD+ precursors into inactive metabolites.

Mechanism of Action

5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide and depletes the NAD+ precursor pool. By blocking NNMT, the compound preserves cellular NAD+ levels and enhances energy expenditure in adipose tissue (Kraus et al., 2014).

Research Applications

NAD+ metabolism and preservation (Kraus et al., 2014)
NNMT enzyme inhibition studies
Metabolic regulation research
Cancer metabolism studies (Eckert et al., 2019)
Product Specifications

Purity: ≥99% (HPLC verified)
Molecular Weight: 173.21 Da
Form: White crystalline powder
Storage: Room temperature, protected from light
References

Kraus D, et al. Nature. 2014. PMID: 24717514
Eckert MA, et al. Nature. 2019. PMID: 31043742